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In clinical trials, two new classes of anti-inflammatory drugs - anti-cytokine monoclonal antibodies and cytokine inhibitors - have been shown to reduce inflammation in a range of autoimmune diseases, and these drugs have already started to be administered to patients who do not respond to standard treatments. Given the potential link between inflammation and depression , Dr.

Biologics for Targeting Inflammatory Cytokines, Clinical Uses, and Limitations

Khandaker and colleagues set out to investigate whether these drugs might also help alleviate symptoms of depression. For their study , the researchers conducted a meta-analysis of 20 clinical trials that assessed the effects of anti-cytokine monoclonal antibodies and cytokine inhibitors in more than 5, patients with autoimmune diseases.

On investigating the additional benefits of the anti-cytokine medications in each trial - seven of which were randomized controlled trials involving a placebo - the team found that the drugs led to a significant reduction in symptoms of depression among participants, regardless of whether they were effective against autoimmune diseases.

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While further studies are required, the researchers say their results suggest anti-cytokine medications may be a feasible treatment option for patients with depression - particularly for those who do not respond to current antidepressants. All currently available antidepressants target a particular type of neurotransmitter, but a third of patients do not respond to these drugs.

We are now entering the era of 'personalized medicine' where we can tailor treatments to individual patients.

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This approach is starting to show success in treating cancers , and it's possible that in future we would use anti-inflammatory drugs in psychiatry for certain patients with depression. Still, the team stresses there is still a long way to go before anti-cytokine medications will be used for depression in clinical practice. Peter Jones, of the Department of Psychiatry at Cambridge.

Learn how the discovery of a new brain pathway could lead to new treatments for depression. Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions , Golam Khandaker et al. University of Cambridge news release , accessed 18 October Additional source: University of Cambridge, Mind and body: Scientists identify immune system link to mental illness , accessed 18 October Visit our Depression category page for the latest news on this subject, or sign up to our newsletter to receive the latest updates on Depression.

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Despite recent advances, main anti-cancer therapies, namely surgery, radiation therapy and chemotherapy, are limited in their ability to treat minimal and metastatic residual disease. Furthermore, the benefit of conventional therapies is often limited by collateral damage to normal tissues. Immunotherapy is a new avenue of cancer treatment being investigated by researchers and clinicians for different cancer types.

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Keywords: Cancer, chemokines, clinical trials, cytokines, immunotherapy, inflammation Abstract: The response of the body to cancer is not a unique mechanism and has many parallels with inflammation and wound healing. Close Print this page. Content: Citation Only. Citation and Abstract. Article Metrics PDF: Related Journals. Related eBooks.